Recently, the professor Xiaoting Jin’s group from department of labor Health and environmental health has great achievement on the effect of fine particulate matter (PM2.5) exposure on myocardial energy metabolism and its related mechanism. Relevant results have been published in Science of the Total Environment (TOP 1, Impact Factor：5.92）and Environmental Pollution (TOP 2, Impact Factor: 5.714) under the title of “Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure” and “Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism”, respectively.
These studies mainly focused on seasonal PM2.5-induced cardiac dysfunction and metabolic remodeling, and the toxicity differences of PM2.5 samples from different sampling seasons and different exposure dosages were discussed. The results showed that seasonal haze caused cardiac dysfunctions and myocardial damage. Comparatively, winter PM2.5 exposure caused more severe cardiac toxicity than did summer haze samples, possibly due to the existence of different components and pollutant levels in seasonal hazes. To further investigate the possible mechanism, Jin’s team conducted research on pollution exposure for the selection and utilization of myocardial energy substrates, changes in key energy metabolism pathways and the effects of energy utilization and storage. Of note, low dose PM2.5 exposure induced the elevation of β-oxidation and TCA cycle as the compensation for the disturbed energy metabolism in animals, whereas high dose of PM2.5 exposure attenuated this process and the glycolysis levels were strikingly promoted, thus causing the reduced energy production and cardiac dysfunction. Meanwhile, the PPARα was found to be a pivotal role in the regulation of myocardial metabolic remodeling incurred by PM2.5. The findings on seasonal PM2.5 induced cardiac dysfunction and myocardial metabolic remodeling provided new insights into cardiovascular disease risks from haze exposure.
The professor Xiaoting Jin is the corresponding author of the two papers, and postgraduate students Jingxu Zhang and Ze Zhang are the first authors of the two articles, respectively. Cooperative units in this research included the Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, University of Shanxi and University of Karachi.
This work was financially supported by the National Natural cience Foundation of China (No. 219761 14, 21707085) and the Taishan Scholars Program of Shandong Province (NO. tsqn201909101).
Figure: Fine particulate matter exposure and energy metabolism remodeling of cardiomyocytes. (DOI: 10.1016/j.scitotenv.2020.137792)
近日，亚搏登录劳动卫生与环境卫生系晋小婷教授团队在研究大气细颗粒物 (PM2.5) 暴露与心肌能量代谢方面取得重要成果，相关成果以“Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure”和“Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism”为题分别发表于国际学术期刊《Science of the Total Environment》(TOP一区，影响因子：5.92）和《Environmental Pollution》(TOP二区，影响因子：5.714)。
晋小婷教授为两篇文章的通讯作者，硕士研究生张京旭和张泽分别为两篇文章的第一作者。本研究合作单位包括中国科学院生态环境研究中心，山西大学以及University of Karachi。
该课题得到国家自然科学基金（Nos. 21976114, 21707085, 21976114和91643203）和山东省泰山青年学者基金（tsqn201909101）的支持。